Key result
Haptoglobin 2-1 phenotype links to greater blood pressure salt sensitivity versus 2-2, unlike ACE genotype.
Why the study?
Is salt sensitivity of blood pressure associated with ACE genotype or haptoglobin phenotype in Japanese patients with essential hypertension?
Observational (n=104)
Is salt sensitivity of blood pressure associated with ACE genotype or haptoglobin phenotype in Japanese patients with essential hypertension?
Salt sensitivity in Japanese patients with essential hypertension is associated with the haptoglobin phenotype but not the ACE genotype.
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Haptoglobin 2-1 phenotype was associated with salt sensitivity in Japanese hypertension; hypothesis-generating and requires prospective validation before clinical use.
Kojima et al. (1994) conducted an observational in essential hypertension (n=104). Haptoglobin phenotype and ACE genotype vs. Alternative phenotypes/genotypes was evaluated on Salt sensitivity of blood pressure. The haptoglobin 2-1 phenotype was significantly associated with greater salt sensitivity of blood pressure compared to the 2-2 phenotype, whereas ACE genotype showed no such association.
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