Why the study?
Does volume-overload experimental heart failure induced by aortocaval fistula alter skeletal muscle phosphate metabolism in rats?
Does volume-overload experimental heart failure induced by aortocaval fistula alter skeletal muscle phosphate metabolism in rats?
Volume-overload experimental heart failure in rats is associated with early skeletal muscle phosphate metabolism abnormalities, specifically a higher rate of phosphocreatine depletion during motor activity.
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Hypothesis-generating for skeletal muscle bioenergetic changes in experimental volume-overload HF; leaves open relevance to human disease.
Chati et al. (1994) studied this question.
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