Key result
Percutaneous coronary intervention was associated with significantly higher mortality (OR 1.79) compared to coronary artery bypass surgery in patients with coronary artery disease and a high SYNTAX score.
Why the study?
Does percutaneous coronary intervention worsen clinical outcomes compared to coronary artery bypass surgery in patients with coronary artery disease and a high SYNTAX score?
Population
1,074 patients with coronary artery disease and a high SYNTAX score (≥33)
Comparison
Percutaneous coronary intervention (PCI) vs Coronary artery bypass surgery (CABG)
Design
Meta-analysis
Authors
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May support CABG preference in high-SYNTAX CAD; hypothesis-generating and requires RCT confirmation.
Meta-Analysis (n=1,074)
Does percutaneous coronary intervention worsen clinical outcomes compared to coronary artery bypass surgery in patients with coronary artery disease and a high SYNTAX score?
Odds Ratio: 1.79 (95% CI 1.18–2.7)
p-value: p=0.006
In patients with complex coronary artery disease (SYNTAX score ≥33), PCI is associated with significantly higher mortality, MI, and repeat revascularization compared to CABG.
Bundhun et al. (2017) conducted a meta-analysis in Coronary artery disease with high SYNTAX score (n=1,074). Percutaneous coronary intervention vs. Coronary artery bypass surgery was evaluated on Mortality (OR 1.79, 95% CI 1.18-2.70, p=0.006). Percutaneous coronary intervention was associated with significantly higher mortality (OR 1.79) compared to coronary artery bypass surgery in patients with coronary artery disease and a high SYNTAX score.
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