Key result
Adding coronary flow reserve assessment by transthoracic Doppler echocardiography to MSCT improved diagnostic accuracy for detecting significant LAD stenosis from 65.07% to 92.72%.
Why the study?
Does the addition of CFR by TDE to MSCT improve diagnostic accuracy for detecting significant LAD stenosis in patients with stable cardiac status?
Observational (n=63)
Does the addition of CFR by TDE to MSCT improve diagnostic accuracy for detecting significant LAD stenosis in patients with stable cardiac status?
Absolute Event Rate: 92.72% vs 65.07%
The addition of coronary flow reserve assessment by transthoracic echocardiography significantly improves the diagnostic accuracy of MSCT for detecting functionally significant LAD stenosis.
May improve noninvasive LAD stenosis detection; extends MSCT data but leaves open prospective validation.
PURPOSE: Multislice computed coronary angiography (MSCT) provides valuable morphological information about coronary artery disease, but precise quantification of coronary stenosis remains difficult. Transthoracic color Doppler echocardiography (TDE) gives a new insight into the functional significance of coronary luminal narrowing. We have tried to assess the additive value of coronary flow reserve (CFR) determined by TDE over MSCT in prediction of a significant stenosis on the left anterior descending artery (LAD) using the invasive coronary angiography (ICA) as a reference method. METHODS: This prospective study included 63 patients in stable cardiac status with previously detected atherosclerotic lesions on LAD by MSCT. CFR assessment by TDE with adenosine infusion was obtained to all patients (feasibility was 96.92%). CFR was determined as ratio between the peak diastolic flow velocity during adenosine infusion and at basal condition, a cutoff value indicating significant stenosis was <2. ICA was preformed to all patients 24-48 hours after CFR. RESULTS: MSCT had sensitivity of 86.36%, specificity 53.66%, positive predictive value 50.00%, negative predictive value 88.00%, and diagnostic accuracy of 65.07% in detection of significant LAD stenosis. CFR had sensitivity 81.81%, specificity 97.06%, positive predictive value 94.74%, negative predictive value 89.19%, and diagnostic accuracy of 91.07%. When the results of both methods were agreed diagnostic accuracy was improved to 92.72%. CONCLUSION: Additional assessment of CFR by TDE increase diagnostic accuracy of MSCT angiography in detection of significant coronary artery lesions.
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Mladenović et al. (2012) conducted an observational in Coronary stenosis (n=63). Coronary flow reserve (CFR) by transthoracic color Doppler echocardiography (TDE) combined with MSCT vs. MSCT alone was evaluated on Diagnostic accuracy for significant LAD stenosis. Adding coronary flow reserve assessment by transthoracic Doppler echocardiography to MSCT improved diagnostic accuracy for detecting significant LAD stenosis from 65.07% to 92.72%.
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