Why the study?
Does atenolol 100 mg reduce blood pressure as effectively as penbutolol 40 mg in patients with moderate hypertension?
Does atenolol 100 mg reduce blood pressure as effectively as penbutolol 40 mg in patients with moderate hypertension?
Atenolol 100 mg and penbutolol 40 mg are equally effective in lowering blood pressure in moderate hypertension, though atenolol is associated with more frequent bradycardia.
Either agent suits moderate hypertension with choice by bradycardia risk; confirms beta-blocker equivalence for BP reduction.
In a randomized controlled, double-blind clinical trial with 45 patients with moderate hypertension atenolol 100 mg and penbutolol 40 mg were equally effective in lowering the blood pressure. During the 6 weeks of treatment there was no change in body weight and serious side-effects were not observed, but bradycardia occurred more frequently with atenolol than with penbutolol. Withdrawal of medication during the final week of the study did not cause any adverse reaction.
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Lameijer et al. (1983) studied this question.
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