Key result
Penbutolol and metoprolol lower blood pressure and pulse rate in moderate hypertension.
Why the study?
Does penbutolol compared to metoprolol improve blood pressure and neurohormonal responses in patients with moderate hypertension?
Does penbutolol compared to metoprolol improve blood pressure and neurohormonal responses in patients with moderate hypertension?
While both penbutolol and metoprolol effectively lower blood pressure and heart rate, penbutolol has distinct effects on suppressing the renin-aldosterone response to exercise.
No takes yet. Share an insight, caveat, or question.
May inform beta-blocker choice by neurohormonal profile; leaves open outcome differences versus metoprolol in larger trials.
Hansson et al. (1983) studied Moderate hypertension (n=14). Penbutolol vs. Metoprolol 50-150 mg three times daily was evaluated on Blood pressure and pulse rate. Penbutolol (20-30 mg twice daily) and metoprolol significantly reduced blood pressure and pulse rate in 14 patients with moderate hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: