Why the study?
Do PPAR agonists prevent ET1-induced hypertrophy in rat cardiomyocytes via a DGKζ-dependent mechanism?
Do PPAR agonists prevent ET1-induced hypertrophy in rat cardiomyocytes via a DGKζ-dependent mechanism?
The anti-hypertrophic actions of PPAR agonists in cardiomyocytes require DGKζ, establishing a PPAR-DGK signalling axis that inhibits ET1-dependent hypertrophy.
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PPAR agonists inhibit ET1-driven hypertrophy via DGKζ in rat cardiomyocytes; leaves open translation to in vivo models or clinical HF therapy.
Huang et al. (2010) studied this question.
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