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April 1, 1980Journal of VirologyOpen Access

Comparative biochemical studies of type 3 poliovirus

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Population

Type 3 poliovirus strains, including Sabin vaccine strains, wild strains, and two viruses isolated from…

Design

Preclinical

Authors

PMPhilip D. MinorUniversity of Essex

Discussion

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Implication

May aid poliovirus strain tracing in research; leaves open human surveillance utility without further validation.

Structured PICO

P
Population
Type 3 poliovirus strains, including Sabin vaccine strains, wild strains, and two viruses isolated from human cases of paralytic poliomyelitis
I
Intervention
Examination of virus-coded polypeptides in infected cells and preparation of oligonucleotide maps
O
Outcome
Differentiation between vaccine and wild strains of poliovirus type 3surrogate

Biochemical analysis of polypeptides and oligonucleotide maps can effectively distinguish between vaccine and wild strains of type 3 poliovirus.

Cite This Study

Philip D. Minor (1980) studied this question.

synapsesocial.com/papers/6a73798f30bc69be694e5fe5https://doi.org/10.1128/jvi.34.1.73-84.1980
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Also Consider

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  1. 1Sequence Studies of Poliovirus RNA. IV. Nucleotide Sequence Complexities of Poliovirus Type 1, Type 2 and Two Type 1 Defective Interfering Particles RNAs, and Fingerprint of the Poliovirus Type 3 Genome1979 · 51 citations
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  3. 3Two initiation sites for translation of poliovirus RNA in vitro: comparison of LSc and Mahoney strains1978 · 22 citations
  4. 4"Fingerprinting" high molecular weight RNA by two-dimensional gel electrophoresis: application to poliovirus RNA1976 · 58 citations
  5. 5Complete translation of poliovirus RNA in a eukaryotic cell-free system.1975 · 90 citations