Why the study?
Does heavy smoking impair endothelium-dependent relaxation in human saphenous veins?
Population
36 samples of proximal saphenous vein obtained from heavy smokers and non-smokers
Comparison
Heavy smoking (exposure) vs Non-smoking
Design
Preclinical
Authors
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Smoking-linked endothelial impairment in saphenous veins may raise graft occlusion risk; leaves open whether cessation alters clinical outcomes.
Does heavy smoking impair endothelium-dependent relaxation in human saphenous veins?
Heavy smoking impairs the release of endothelium-derived relaxing factor in saphenous veins, which may increase vasomotor tone and the risk of graft occlusion.
Higman et al. (1993) studied this question.
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