Why the study?
Does once-daily administration of pindolol or propranolol control blood pressure similarly to three-times-daily administration?
Does once-daily administration of pindolol or propranolol control blood pressure similarly to three-times-daily administration?
Once-daily dosing of beta-blockers like pindolol or propranolol is as effective as three-times-daily dosing for blood pressure control, with effects persisting beyond 24 hours after discontinuation.
Answers are grounded in this paper and cite their sources.
May support once-daily beta-blocker dosing for hypertension; leaves open confirmation in larger randomized trials.
The control of blood pressure achieved was similar whether pindolol or propranolol was given once or three times daily. When the drugs were ceased the antihypertensive effect lasted for longer than 24 h. There was no rebound hypertension. The full effect of the drug on blood pressure was seen within 24 h of its recommencement. Changes in blood pressure, pulse rate, and plasma renin activity occurred but these were not considered to be causally related. The response of plasma renin activity to posture was ablated when the patients were receiving beta-adrenoceptor blocking drugs.
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Wilson et al. (1976) studied this question.
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