Population
15 humans, comprising patients with chronic heart failure and controls of similar age and physical activity.
Design
Case-control
Authors
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May explain skeletal muscle weakness in chronic heart failure; hypothesis-generating for myosin-targeted interventions.
Chronic heart failure alters skeletal muscle contraction at the level of the myosin-actin cross-bridge, which may contribute to impaired muscle function in these patients.
Miller et al. (2010) studied this question.
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