Why the study?
Does transient CD154 blockade ameliorate disease progression in mice with Theiler's murine encephalomyelitis virus-induced demyelinating disease?
Does transient CD154 blockade ameliorate disease progression in mice with Theiler's murine encephalomyelitis virus-induced demyelinating disease?
Transient CD154 blockade delays but does not permanently prevent disease progression in a murine model of virus-induced demyelinating disease.
May transiently slow progression in this murine model; leaves open whether sustained CD154 blockade alters long-term outcomes in virus-induced demyelination.
Transient CD154 blockade at the onset of Theiler's murine encephalomyelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced immune cell infiltration, and transiently increased viral loads in the central nervous system. Peripheral antiviral and autoimmune T-cell responses were normal, and disease severity returned to control levels by day 120.
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Howard et al. (2003) studied this question.
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