What question did this study set out to answer?

To evaluate left ventricular mass as an integrative biomarker of preclinical cardiovascular risk and target-organ damage in hypertensive patients.

June 1, 1992American Journal of Hypertension

Left Ventricular Mass as a Measure of Preclinical Hypertensive Disease

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Why the study?

Does left ventricular mass measurement predict subsequent morbid events and death better than conventional risk factors in hypertensive patients?

Population

Hypertensive patients in the presymptomatic phase

Comparison

Measurement of left ventricular mass by… vs Blood pressure or other conventional risk factors

Design

Review

Authors

RDRichard B. DevereuxBoston University MKMichael J. KorenFar Eastern Scientific Centre of Physiology and Pathology of Respiration Russian Academy of Medical Sciences GSGiovanni de SimonePreventive Cardiology

Discussion

Member takes

Implication

LV mass may refine risk stratification in hypertension; extends prospective observational data but leaves open whether regression alters outcomes.

Key Points

To evaluate left ventricular mass as an integrative biomarker of preclinical cardiovascular risk and target-organ damage in hypertensive patients.
Reviewed prospective evidence assessing echocardiographic left ventricular mass measurements across hypertensive cohorts.
Analyzed the relationship between left ventricular enlargement, underlying physiological drivers (dietary sodium, blood viscosity, obesity, genetics), and cardiovascular morbidity and mortality.
Left ventricular mass independently predicted subsequent cardiovascular morbid events and mortality more strongly than resting blood pressure or other conventional risk factors except age.
Elevated left ventricular mass correlated closely with preclinical arterial disease, and treatment-induced regression of mass was associated with reduced clinical events.

Structured PICO

Does left ventricular mass measurement predict subsequent morbid events and death better than conventional risk factors in hypertensive patients?

Population

Hypertensive patients in the presymptomatic phase

Intervention

Measurement of left ventricular (LV) mass by echocardiography

Comparator

Blood pressure or other conventional risk factors

Outcome

Subsequent morbid events and deathsurrogate

Left ventricular mass measured by echocardiography is a strong predictor of morbid events and death in preclinical hypertensive disease, outperforming conventional risk factors other than age.

Cite This Study

Devereux et al. (1992) studied this question.

synapsesocial.com/papers/6a7440f373ed22dccea7f9ae https://doi.org/10.1093/ajh/5.6.175s

Topics

Hypertension management Echocardiography

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Implication

LV mass may refine risk stratification in hypertension; extends prospective observational data but leaves open whether regression alters outcomes.

Left Ventricular Mass as a Measure of Preclinical Hypertensive Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Left Ventricular Mass as a Measure of Preclinical Hypertensive Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider