Key result
ANGPTL2 overexpression induced androgen-independent progression and malignant behavior in human prostate cancer cells, whereas its knockdown significantly suppressed cell proliferation, migration, and invasion.
Population
Human prostate cancer cell lines and human prostate cancer specimens.
Comparison
Overexpression of ANGPTL2 via cDNA transfection… vs Control siRNA, empty control vector, control…
Design
Preclinical
Authors
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May support ANGPTL2 as a therapeutic target in androgen-independent prostate cancer; animal data leave open clinical translation.
p-value: p=<0.05
ANGPTL2 promotes androgen-independent progression and malignant behavior in prostate cancer cells via the integrin α5β1 receptor, highlighting it as a potential therapeutic target.
Sato et al. (2014) studied Prostate cancer (n=10). ANGPTL2 overexpression or knockdown vs. Wild-type cells, control siRNA, or empty vector was evaluated on Cell proliferation, migration, and invasion (p=<0.05). ANGPTL2 overexpression induced androgen-independent progression and malignant behavior in human prostate cancer cells, whereas its knockdown significantly suppressed cell proliferation, migration, and invasion.
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