Key result
Intracerebroventricular administration of captopril significantly increased the time rats spent in the open arms of the elevated plus maze (p=0.0009) and decreased oxidative stress, whereas angiotensin II induced anxiety-like behavior.
Why the study?
Does central administration of captopril reduce anxiety and brain oxidative stress in rats?
Population
36 experimentally naive, male Wistar rats, weighing approximately 200-250 g
Comparison
Captopril or angiotensin II administered… vs Sham-operated rats injected with saline…
Design
Preclinical
Follow-up
7 days
Authors
Loading...
Central captopril may reduce anxiety-like behavior in rats; leaves open translation to human anxiety disorders.
Does central administration of captopril reduce anxiety and brain oxidative stress in rats?
p-value: p=0.0009
Central administration of the ACE inhibitor captopril exerts anxiolytic effects and reduces oxidative stress in the temporal lobe of rats.
Ciobîcă et al. (2011) studied Anxiety and oxidative stress (n=36). Captopril and Angiotensin II vs. Saline (sham-operated control) was evaluated on Time spent in the open arms of the elevated plus maze (p=0.0009). Intracerebroventricular administration of captopril significantly increased the time rats spent in the open arms of the elevated plus maze (p=0.0009) and decreased oxidative stress, whereas angiotensin II induced anxiety-like behavior.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: