Key result
Angiotensin-(1-9) reduced established hypertension, ameliorated structural alterations, and improved cardiac and endothelial function in hypertensive rats via the AT2 receptor.
Why the study?
Does angiotensin-(1-9) reduce hypertension and reverse experimental cardiovascular damage in hypertensive rats?
Population
Rats with early high blood pressure induced by angiotensin II infusion or renal artery clipping
Design
Preclinical
Follow-up
2 weeks
Authors
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Hypothesis-generating in rat models; leaves open clinical translation of AT2 agonism for human hypertension.
Does angiotensin-(1-9) reduce hypertension and reverse experimental cardiovascular damage in hypertensive rats?
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular remodeling in rats via the AT2 receptor, suggesting a potential therapeutic pathway.
Ocaranza et al. (2014) studied Hypertension and cardiovascular damage. Angiotensin-(1-9) was evaluated on Hypertension, cardiac and endothelial function, hypertrophy, fibrosis, and oxidative stress. Angiotensin-(1-9) reduced established hypertension, ameliorated structural alterations, and improved cardiac and endothelial function in hypertensive rats via the AT2 receptor.
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