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August 1, 2026Biomedical JournalOpen Access

Distinguishing true from false idiopathic pulmonary fibrosis: Progress in biomarkers for early identification of rheumatoid arthritis

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Authors

YSYu SuXQXi QinLGLuhan Guo

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Overview

Literature review identifies predictive biomarkers for rheumatoid arthritis transition in idiopathic pulmonary fibrosis, highlighting pathways for early pre-arthritic screening.

Key Points

  • To comprehensively review and summarize predictive biomarkers that signal future rheumatoid arthritis development in patients initially meeting diagnostic criteria for idiopathic pulmonary fibrosis.
  • Conducted a structured literature search in the PubMed database covering the years 2001 to 2025 using combinations of terms related to idiopathic pulmonary fibrosis, rheumatoid arthritis, predictive markers, and mechanistic pathways.
  • Characterized four primary predictive marker domains driving the transition from pulmonary autoimmunity to systemic disease: genetic susceptibility, immune activation, inflammatory injury, and environmental exposure.
  • Identified that existing literature predominantly consists of cross-sectional and retrospective designs, highlighting an absence of prospective cohort validation, combinatorial scoring systems, and validated microbiome markers.

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/6a74c52401b447f0dadbe939https://doi.org/10.1016/j.bj.2026.101021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Performance of an Idiopathic Pulmonary Fibrosis Derived Multibiomarker Panel for Rheumatoid Arthritis‐Associated Interstitial Lung Disease2025
  2. 2Comparison between patients with idiopathic pulmonary fibrosis and patients with pulmonary involvement of the usual interstitial pneumonia pattern that preceded the onset of rheumatoid arthritis2014
  3. 3Biomarkers in idiopathic pulmonary fibrosis: Current insight and future direction2024 · 42 citations
  4. 4Single-Cell Analysis Identifies Factors Associated with Rheumatoid Arthritis-Related Interstitial Lung Disease in Comparison with Idiopathic Pulmonary Fibrosis2026
  5. 5Markers of the early stage of rheumatoid arthritis2016