Key result
Major risk allele homozygotes (TT) at the SORT1 locus had higher fasting VLDL particles and elevated postprandial VLDL and triglycerides.
Why the study?
Does the SORT1 1p13 locus TT genotype increase postprandial lipaemia following a high fat meal in healthy young adults compared to the TC/CC genotype?
Observational (n=30)
Does the SORT1 1p13 locus TT genotype increase postprandial lipaemia following a high fat meal in healthy young adults compared to the TC/CC genotype?
The SORT1 1p13 TT risk allele is associated with increased fasting and postprandial atherogenic lipoproteins in healthy young adults, highlighting a potential genetic target for early atherosclerosis prevention.
Answers are grounded in this paper and cite their sources.
SORT1 TT genotype may inform genetic risk stratification; leaves open whether targeting this locus alters long-term cardiovascular outcomes.
Elevations in low‐density lipoproteins (LDL), very‐low density lipoproteins (VLDL) and triglycerides (TG) in the postprandial state have a strong genetic component and recognized atherogenic potential. We sought to determine if there is a difference in postprandial lipaemia following an oral fat tolerance test when stratified by genotype at the SORT1 1p13 locus, the strongest LDL‐cholesterol associated locus identified to date. Thirty, healthy young adults (age=23.57) received a high fat, mixed meal (91 g, 55% kcal from fat). Blood samples drawn at fasting, 2, 4, 8 and 24 hrs postprandial, underwent comprehensive lipoprotein analyses via nuclear magnetic resonance profiling. At fasting, VLDL particles differed based upon SORT1 genotype (TT: 48.81±5.07 nmol/L versus TC/CC: 30.05±2.99 nmol/L, p=0.004). Major, risk allele homozygotes (TT) had significantly elevated area‐under‐the‐curve and mean concentration for VLDL particles, TG and VLDL‐TG (p<0.05). These results indicate increased fasting and postprandial exposure to atherogenic particles in TT homozygotes. This highlights SORT1 as a valuable target for identifying individuals for early, personalized interventions to prevent atherosclerosis.
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Connors et al. (2014) conducted an observational in Healthy (n=30). SORT1 1p13 locus TT genotype vs. TC/CC genotype was evaluated on Fasting VLDL particles (nmol/L) (p=0.004). Major risk allele homozygotes (TT) at the SORT1 locus had higher fasting VLDL particles and elevated postprandial VLDL and triglycerides.
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