Alterations in Central Blood Volume and Cardiac Output Induced by Positive Pressure Breathing and Counteracted by Metaraminol (Aramine)
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Discussion
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Implication
Experimental study shows metaraminol restores cardiac output and blood volume during positive pressure breathing in dogs, suggesting improved vascular tone and contractility.
Key Points
- To determine the circulatory effects of positive pressure breathing and evaluate whether metaraminol can restore central blood volume and cardiac output.
- Subjected canine models to high levels of positive pressure breathing.
- Administered metaraminol during continuous positive pressure breathing and monitored circulatory and hemodynamic parameters.
- High levels of positive pressure breathing caused substantial reductions in central blood volume, cardiac output, and arterial pressure.
- Administration of metaraminol elevated central blood volume, cardiac output, and arterial pressure while positive pressure breathing was actively maintained.
Cite This Study
Braunwald et al. (1957) studied this question.