Block of intercellular communication: interaction of intracellular H+ and Ca2+

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Population

Cultured neonatal rat myocardial cells

Comparison

Combined elevation of intracellular H+ and… vs Control conditions, intracellular acidosis…

Design

Preclinical

Authors

Discussion

Hypothesis-generating for ischemic gap junction modulation in myocardium; leaves open translation to human arrhythmias without in vivo data.

Population

Cultured neonatal rat myocardial cells

Intervention

Combined elevation of intracellular H+ (acidosis) and intracellular Ca2+

Comparator

Control conditions, intracellular acidosis alone, or elevation of intracellular Ca2+ alone

Outcome

Percent of primary neighboring cells to which intracellularly injected Lucifer yellow had spread within 10 s of injectionsurrogate

Intracellular Ca2+ and H+ act synergistically to regulate junctional permeability and block intercellular communication in myocardial cells.

Janis M. Burt (1987) studied this question.

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Hypothesis-generating for ischemic gap junction modulation in myocardium; leaves open translation to human arrhythmias without in vivo data.