June 24, 2014European Journal of Heart Failure
Transcatheter Treatment of Heart Failure with Preserved or Mildly Reduced Ejection Fraction Using a Novel Interatrial Implant to Lower Left Atrial Pressure
Why the study?
Does a novel interatrial septal device reduce left ventricular filling pressures and improve symptoms in patients with HFpEF?
Population
11 patients with heart failure with preserved or mildly reduced ejection fraction. Mean age 70 ± 12 years.
Design
Case_series
Follow-up
30 days
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for interatrial shunting in HFpEF; larger randomized trials needed before clinical adoption.
Structured PICO
Does a novel interatrial septal device reduce left ventricular filling pressures and improve symptoms in patients with HFpEF?
P
Population
11 patients with heart failure with preserved or mildly reduced ejection fraction (EF >45%; baseline PCWP ≥15 mmHg at rest, or ≥25 mmHg at exercise; and ≥1 hospitalization for heart failure within the past 12 months, or persistent NYHA class III/IV for at least 3 months). Mean age 70 ± 12 years.
I
Intervention
Interatrial septal device (IASD) creating an 8 mm permanent shunt, implanted using percutaneous trans-septal access via the femoral vein.
O
Outcome
Left ventricular filling pressures and NYHA class at 30 dayssurrogate
A novel interatrial septal device successfully reduced left ventricular filling pressures and improved symptoms at 30 days in a small pilot cohort of patients with HFpEF.
Cite This Study
Søndergaard et al. (2014) studied this question.