Key result
Deletion of the angiotensin type 1A receptor from catecholaminergic cells delayed the onset and reduced the maximal response of angiotensin-dependent hypertension.
Stimulation of the angiotensin type 1A receptor on catecholaminergic cells is required for the full development of angiotensin-dependent hypertension and cardiac hypertrophy.
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Identifies central AT1A receptors as key in angiotensin-dependent hypertension in mice; leaves open translation to human therapy.
Jancovski et al. (2013) studied Angiotensin-dependent hypertension. Deletion of angiotensin type 1A receptor from catecholaminergic cells was evaluated on Development of angiotensin-dependent hypertension. Deletion of the angiotensin type 1A receptor from catecholaminergic cells delayed the onset and reduced the maximal response of angiotensin-dependent hypertension.
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