The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain.

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Population

COS cells expressing recombinant human U1-70K protein

Design

Preclinical

Authors

Discussion

Hypothesis-generating for snRNP transport; leaves open human relevance pending further validation.

Population

COS cells expressing recombinant human U1-70K protein

Intervention

Deletion analysis and site-directed mutagenesis of the U1-70K protein

Outcome

Nuclear localization of the U1-70K proteinsurrogate

The U1-70K protein can be transported to the nucleus independently of U1 RNA via specific nuclear localization signals.

Romac et al. (1994) studied this question.

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