July 1, 1994Molecular and Cellular Biology

The U1 Small Nuclear Ribonucleoprotein (snRNP) 70K Protein Is Transported Independently of U1 snRNP Particles via a Nuclear Localization Signal in the RNA-Binding Domain

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Population

COS cells expressing recombinant human U1-70K protein

Design

Preclinical

Authors

JRJoelle RomacDuke University DGDavid H. GraffDuke Medical Center JKJack D. KeeneDuke Medical Center

Discussion

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Implication

These NLS may influence cardiac spliceosome function; leaves open roles in disease and requires validation in relevant models.

Structured PICO

Population

COS cells expressing recombinant human U1-70K protein

Intervention

Deletion analysis and site-directed mutagenesis of the U1-70K protein

Outcome

Nuclear localization and transport of the U1-70K protein

The study identifies specific nuclear localization signals in the U1-70K protein, demonstrating its ability to enter the nucleus independently of U1 RNA.

Cite This Study

Romac et al. (1994) studied this question.

synapsesocial.com/papers/6a8ba9779d5fb440a3beb29b https://doi.org/10.1128/mcb.14.7.4662-4670.1994

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The U1 Small Nuclear Ribonucleoprotein (snRNP) 70K Protein Is Transported Independently of U1 snRNP Particles via a Nuclear Localization Signal in the RNA-Binding Domain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The U1 Small Nuclear Ribonucleoprotein (snRNP) 70K Protein Is Transported Independently of U1 snRNP Particles via a Nuclear Localization Signal in the RNA-Binding Domain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider