January 1, 1987Nucleic Acids ResearchOpen Access

The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding

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Population

Human U1-70K snRNP protein cDNA clones

Design

Preclinical

Authors

RSRichard A. SpritzRegeneron (United States)KSKathleen M. StrunkUniversity of Tulsa CSCarol S. SurowyUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

Maps U1AP1 locus and isoforms; leaves open functional roles in RNA splicing and disease relevance.

Structured PICO

Population

Human U1-70K snRNP protein cDNA clones

Intervention

cDNA cloning, sequencing, chromosomal mapping, and in vitro RNA-binding assay

Outcome

Characterization of the human U1-70K snRNP protein gene (U1AP1), including chromosomal localization, RNA transcript sizes, protein size, and alternative splicingsurrogate

The study characterizes the human U1-70K snRNP protein gene, revealing its chromosomal location, RNA-binding capability, and potential for multiple protein isoforms via alternative splicing.

Cite This Study

Spritz et al. (1987) studied this question.

synapsesocial.com/papers/6a89d541a14d41d02f432ee7 https://doi.org/10.1093/nar/15.24.10373

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The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider