Key result
Enterovirus central nervous system infection was associated with higher first-year mortality (MRR 10.0; 95% CI 4.17-24.1), but long-term survival and social functioning were similar to controls.
Why the study?
The long-term clinical course of patients with an enterovirus central nervous system infection is poorly understood.
Cohort (n=19,195)
Yes
Answers are grounded in this paper and cite their sources.
May warrant early vigilance after enterovirus CNS infection; leaves open causal mechanisms and modifiable factors in larger cohorts.
BACKGROUND: The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood. METHODS: We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997-2016 (n = 1745) and a comparison cohort from the general population individually matched on date of birth and sex (n = 17 450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae: neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency. RESULTS: Mortality in the first year was higher among patients with ECI (mortality rate ratio [MRR] = 10.0; 95% confidence interval [CI], 4.17-24.1), but thereafter mortality was not higher (MMR = 0.94; 95% CI, 0.47-1.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency. CONCLUSIONS: Diagnosis of an ECI had no substantial impact on long-term survival, health, or social/educational functioning.
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Omland et al. (2020) conducted a cohort in Enterovirus central nervous system infection (n=19,195). Enterovirus central nervous system infection vs. General population was evaluated on Mortality in the first year (MRR 10.0, 95% CI 4.17-24.1). Enterovirus central nervous system infection was associated with higher first-year mortality (MRR 10.0; 95% CI 4.17-24.1), but long-term survival and social functioning were similar to controls.
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