Why the study?
Does papaverine alter coronary vasodilation, ventricular fibrillation threshold, and conductivity in a dog's heart model?
Population
Dog's heart model
Design
Preclinical
Authors
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May inform vasodilator development with antiarrhythmic potential; leaves open human translation pending safety trials.
Does papaverine alter coronary vasodilation, ventricular fibrillation threshold, and conductivity in a dog's heart model?
In a canine model, papaverine demonstrates significant coronary vasodilatory and anti-fibrillatory effects, though high doses can induce conduction blocks.
Stephen R. Elek (1942) studied this question.
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