Key result
Adolescents with irritable bowel syndrome exhibited significantly reduced total power of heart rate variability during orthostasis compared to healthy controls, which negatively correlated with somatization scores.
Why the study?
Autonomic regulation changes and psychological distress play an important role in irritable bowel syndrome pathobiology, but autonomic function and its link to somatization levels needed evaluation in adolescents with IBS.
Cross-Sectional (n=65)
No
Absolute Event Rate: 2952% vs 4390%
p-value: p=0.005
Adolescents with IBS exhibit autonomic dysfunction during orthostatic challenge, which correlates with increased somatization scores.
Autonomic changes during orthostasis link to somatization in adolescent IBS; hypothesis-generating and needs prospective validation before any clinical role.
Background/Aims: Changes in autonomic regulation and psychological distress play an important role in the pathobiology of irritable bowel syndrome (IBS). The aim of the current study is to evaluate the autonomic function and to link it to the levels of somatization in adolescents with IBS. Methods: We enrolled 30 adolescents with various types of IBS and 35 healthy controls. Time and frequency domain indexes of heart rate variability (HRV) were measured in supine (baseline) and standing (orthostasis) positions using short-term electrocardiographic recordings. The somatic symptoms index was assessed with the modified Screening for Somatoform Symptoms questionnaire. Results: in the supine position demonstrated significantly reduced activity of the low frequency component. Conclusions: Adolescents with IBS showed signs of autonomic dysfunction only during the orthostatic test, which were associated with increased somatization scores. Further research is needed to establish the links between emotional wellbeing and autonomic function in this population.
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Semen et al. (2023) conducted a cross-sectional in Irritable Bowel Syndrome (n=65). Irritable Bowel Syndrome vs. Healthy controls was evaluated on Total power (TP) of heart rate variability in orthostatic position (p=0.005). Adolescents with irritable bowel syndrome exhibited significantly reduced total power of heart rate variability during orthostasis compared to healthy controls, which negatively correlated with somatization scores.
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