Key result
Type 2 diabetes mellitus was associated with significantly elevated plasma levels of ANGPTL8 (531.40 vs 414.27 ng/L) and alarin (16.79 vs 12.36 ng/mL) compared to healthy controls.
Why the study?
Type 2 diabetes mellitus is a major global public health problem, prompting examination of ANGPTL8 and alarin levels in patients with T2DM compared with healthy controls.
Are ANGPTL8 and alarin levels elevated in patients with newly diagnosed type 2 diabetes mellitus compared to healthy controls?
Cross-Sectional (n=122)
No
Are ANGPTL8 and alarin levels elevated in patients with newly diagnosed type 2 diabetes mellitus compared to healthy controls?
Absolute Event Rate: 531.4% vs 414.27%
p-value: p=<0.05
Plasma levels of ANGPTL8 and alarin are significantly elevated in patients with newly diagnosed, treatment-naive type 2 diabetes mellitus, suggesting a potential role in insulin resistance and diabetes pathophysiology.
Purpose: Type 2 Diabetes Mellitus (T2DM) is one of the most serious public health problems that affect millions of people worldwide. There are 537 million adults diagnosed with diabetes worldwide and approximately 90% of these adults have type 2 diabetes. The study examined angiopoietin-like protein 8 (ANGPTL8) and Alarin levels of the patients diagnosed with T2DM in comparison with each other and with the healthy control group. Materials and Methods: The study was conducted with a diabetes group consisting of 67 patients who were newly diagnosed with T2DM and who did not use any medication, and the control group consisting of 55 healthy people. ANGPTL8 and Alarin levels were measured using the ELISA (enzyme-linked immunosorbent assay) method. Results: We found a significant increase in alarin and ANGPTL8 levels in the diabetic group compared to the control group. Furthermore, a positive correlation between Alarin levels and ANGPTL8, triglyceride, and insulin levels was found in the patient group. In addition, while both adipokines were higher in males in the patient group, both adipokines levels were lower in males than females in the control group, and there was a significant difference in ANGPTL8 levels. Conclusion: High levels of ANGPTL8 and Alarin may facilitate the development of diabetes through the insulin resistance pathway. If this mechanism is more clearly elucidated, there may be a significant improvement in diabetic treatment projection.
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Timurkaan et al. (2022) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=122). Type 2 diabetes mellitus vs. Healthy controls was evaluated on Plasma ANGPTL8 levels (ng/L) (p=<0.05). Type 2 diabetes mellitus was associated with significantly elevated plasma levels of ANGPTL8 (531.40 vs 414.27 ng/L) and alarin (16.79 vs 12.36 ng/mL) compared to healthy controls.
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