What question did this study set out to answer?

March 5, 1970New England Journal of Medicine

Treatment of Essential Hypertension with a New Vasodilator in Combination with Beta-Adrenergic Blockade

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Why the study?

Does a piperidino-pyrimidine vasodilator (PDP) combined with propranolol reduce blood pressure without adverse reflex cardiac activity in hypertensive patients?

Population

11 hypertensive patients

Comparison

Piperidino-pyrimidine vasodilator combined with… vs Baseline and PDP monotherapy

Design

Case_series

Follow-up

six to seven days

Authors

EGEdward D. GilmoreUniversity of Waterloo JWJohn V. WeilWebb Institute CCCharles A. ChidseyNational Institutes of Health

Discussion

Member takes

Implication

May support PDP-propranolol for hypertension; leaves open confirmation in randomized trials.

Key Points

To evaluate the efficacy and safety of a new vasodilator in combination with beta-adrenergic blockade in treating essential hypertension.
Administered a piperidino-pyrimidine vasodilator (PDP) to 11 hypertensive patients over 6-7 days.
Monitored blood pressure response, heart rate, cardiac index, and norepinephrine excretion before and after propranolol administration.
Assessed postural symptoms and renal function including glomerular filtration rate.
Blood pressure decreased from 188/124 to 159/100 mmHg (p<0.05).
Reflex increases in heart rate and norepinephrine excretion occurred despite blood pressure reduction.
Sodium retention was noted in all patients, manageable with diuretics.

Structured PICO

Does a piperidino-pyrimidine vasodilator (PDP) combined with propranolol reduce blood pressure without adverse reflex cardiac activity in hypertensive patients?

Population

11 hypertensive patients

Intervention

Piperidino-pyrimidine vasodilator (PDP) combined with propranolol (selective beta-adrenergic blockade)

Comparator

Baseline and PDP monotherapy

Outcome

Blood pressuresurrogate

The combination of a piperidino-pyrimidine vasodilator with propranolol effectively lowers blood pressure while preventing the reflex cardiac stimulation and ischemia associated with the vasodilator alone.

Cite This Study

Gilmore et al. (1970) studied this question.

synapsesocial.com/papers/6a75cd2a117c5bc884dd7ee5 https://doi.org/10.1056/nejm197003052821001

Topics

Hypertension management

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Treatment of Essential Hypertension with a New Vasodilator in Combination with Beta-Adrenergic Blockade

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Treatment of Essential Hypertension with a New Vasodilator in Combination with Beta-Adrenergic Blockade

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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