Why the study?
Does renal artery denervation reduce systolic blood pressure in patients with resistant hypertension?
Population
Patients with resistant hypertension
Comparison
Renal artery denervation vs Sham control
Design
Review
Follow-up
6 months
Key result
Renal artery denervation did not significantly reduce systolic blood pressure at 6 months compared with a sham control in patients with resistant hypertension (-14 ± 24 vs -12 ± 26 mmHg).
Authors
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Renal denervation should not yet alter resistant hypertension management; leaves open refined patient selection and technique optimization for future trials.
Does renal artery denervation reduce systolic blood pressure in patients with resistant hypertension?
Absolute Event Rate: -14% vs -12%
The review explores potential basic and clinical factors that may explain the failure of the Symplicity-3HTN trial to show efficacy for renal artery denervation in resistant hypertension.
Benjamin J. Scherlag (2015) conducted a review in resistant hypertension. renal artery denervation vs. sham control was evaluated on reduction of systolic blood pressure. Renal artery denervation did not significantly reduce systolic blood pressure at 6 months compared with a sham control in patients with resistant hypertension (-14 ± 24 vs -12 ± 26 mmHg).
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