Key result
Longitudinal stimulation and biphasic waveforms independently lowered the excitation threshold of isolated ventricular myocytes, suggesting their combination may decrease energy requirements.
Why the study?
Does longitudinal stimulation and biphasic waveform reduce the excitation threshold in isolated ventricular myocytes?
Does longitudinal stimulation and biphasic waveform reduce the excitation threshold in isolated ventricular myocytes?
Combining longitudinal stimulation and biphasic waveforms additively decreases the energy requirement for myocardial stimulation in isolated ventricular myocytes.
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Should not alter pacing practices; leaves open whether combined longitudinal-biphasic stimulation reduces energy needs in vivo.
Bassani et al. (2006) studied isolated ventricular myocytes. Longitudinal stimulation and biphasic waveforms vs. Transversal stimulation and monophasic waveforms was evaluated on Excitation threshold (E(T)) and maximal variation in membrane potential at threshold (DeltaV(T)). Longitudinal stimulation and biphasic waveforms independently lowered the excitation threshold of isolated ventricular myocytes, suggesting their combination may decrease energy requirements.
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