Why the study?
Altered vascular-related genes are linked to uterine leiomyoma development, and ACE gene polymorphisms are associated with vascular diseases, but their relationship with uterine leiomyoma risk in an Iranian population needed investigation.
Do ACE I/D and AGTR1 A1166C gene polymorphisms increase the risk of uterine leiomyoma in women?
Do ACE I/D and AGTR1 A1166C gene polymorphisms increase the risk of uterine leiomyoma in women?
The ACE ID and DD genotypes are associated with a higher risk of uterine leiomyoma in an Iranian population, whereas the AGTR1 A1166C polymorphism showed no significant association.
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ACE I/D variants linked to higher UL risk in Iranian women; hypothesis-generating, needs replication before any clinical or screening implications.
Keshavarzi et al. (2019) studied this question.
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