March 28, 2014BMC Research NotesOpen Access

Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population

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Population

116 unrelated healthy Zambian adults, aged 25-60 years. Excluded: major neurological diseases, stroke risk…

Design

Cross-sectional

Authors

MAMasharip AtadzhanovUniversity of Zambia MMMwila Hilton MwabaHokkaido University PMPatrice MukomenaUniversity of Zambia

Discussion

Member takes

Implication

Provides baseline allele frequencies in Zambians; leaves open links to cardiovascular risk pending prospective validation.

Structured PICO

Population

116 unrelated healthy Zambian adults (68 women, 48 men), aged 25-60 years (mean age 44 ± 16). Excluded: major neurological diseases, stroke risk factors (hypertension, severe coronary artery disease, diabetes mellitus, hyperlipidemia), pregnant women, and HIV positive subjects.

Outcome

Allelic and genotypic frequencies of APOE, MTHFR C677T and ACE I/D gene polymorphisms

This study establishes baseline genetic frequencies for APOE, MTHFR, and ACE polymorphisms in the Zambian population, showing high prevalence of APOE ε3 and ACE I alleles, which may inform future cardiovascular and neurological disease risk assessments.

Limitations

Small sample size cannot be representative of all the Zambian population
Lack of coverage from most African countries, particularly regarding the studies of the MTHFR C677T and the ACE I/D polymorphisms

Cite This Study

Atadzhanov et al. (2014) studied this question.

synapsesocial.com/papers/6a760b2149a8cdd61fb1ed2c https://doi.org/10.1186/1756-0500-7-194

Topics

Women and heart disease

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Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider