Why the study?
Does Angiopoietin-1 reduce VEGF- and TNF-a-induced tissue factor expression in human umbilical vein endothelial cells?
Population
Human umbilical vein endothelial cells (HUVECs)
Comparison
Angiopoietin-1 and adenoviral transfer for PI… vs Untreated cells or cells treated with VEGF and…
Design
Preclinical
Authors
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Hypothesis-generating for Ang1 in limiting endothelial procoagulant activity; in vivo studies needed before clinical exploration.
Does Angiopoietin-1 reduce VEGF- and TNF-a-induced tissue factor expression in human umbilical vein endothelial cells?
Angiopoietin-1 inhibits VEGF- and TNF-a-induced tissue factor expression in endothelial cells via the PI 3'-kinase/Akt pathway, suggesting potential utility against coagulation and inflammation.
Kim et al. (2001) studied this question.
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