January 1, 2001Cardiovascular ResearchOpen Access

Cysteinyl leukotrienes are involved in angiotensin II-induced contraction of aorta from spontaneously hypertensive rats

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Structured PICO

Population

Rings of thoracic aorta from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)

Intervention

Angiotensin II with or without pretreatment with 5-lipoxygenase inhibitor AA861 (10 microM), CysLT(1) receptor antagonist MK571 (1 microM), AT(1) receptor antagonist losartan (1 microM), or AT(2) receptor antagonist PD123319 (0.1 microM)

Comparator

Control (no pretreatment) and aorta rings from normotensive Wistar-Kyoto rats (WKY)

Outcome

Contractile responses and release of cysteinyl leukotrienes in response to angiotensin IIsurrogate

Cysteinyl leukotrienes, acting partly on endothelial CysLT(1) receptors, mediate the contractile response to angiotensin II in the aorta of spontaneously hypertensive rats.

Discussion

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Implication

Does not support clinical use of 5-lipoxygenase inhibition; leaves open leukotriene mediation of angiotensin II effects in human hypertension.

Cite This Study

F. Stanke-Labesque (2001) studied this question.

synapsesocial.com/papers/6a761f2274b63c188eb21ca5 https://doi.org/10.1016/s0008-6363(00)00238-8

Topics

Hypertension management

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Implication

Does not support clinical use of 5-lipoxygenase inhibition; leaves open leukotriene mediation of angiotensin II effects in human hypertension.

Cysteinyl leukotrienes are involved in angiotensin II-induced contraction of aorta from spontaneously hypertensive rats

Structured PICO

Discussion

Implication

Cite This Study

Topics

Cysteinyl leukotrienes are involved in angiotensin II-induced contraction of aorta from spontaneously hypertensive rats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider