May 1, 1976Biotechnology and Bioengineering

The production of foot‐and‐mouth disease virus from BHK 21 C 13 cells grown on the surface of DEAE sephadex A50 beads

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Population

BHK 21 C13 monolayer cells

Comparison

Grown on the surface of serum coated DEAE… vs Conventional Roux monolayer systems

Design

Preclinical

Authors

RSR.E. SpierAmsterdam University Medical Centers JWJ. P. WhitesideUniversity of Surrey

Discussion

Member takes

Implication

May support microcarrier systems for FMD virus production; leaves open scale-up validation and regulatory adoption.

Structured PICO

Population

BHK 21 C13 monolayer cells

Intervention

Grown on the surface of serum coated DEAE Sephadex A50 beads

Comparator

Conventional Roux monolayer systems

Outcome

Yield of cells and their susceptibility to infection by foot-and-mouth disease (FMD) virussurrogate

Growing BHK 21 C13 cells on DEAE Sephadex A50 beads provides equivalent cell yield and FMD virus susceptibility compared to conventional Roux monolayer systems.

Cite This Study

Spier et al. (1976) studied this question.

synapsesocial.com/papers/6a763ae0fa1990f79e614a11 https://doi.org/10.1002/bit.260180506

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The production of foot‐and‐mouth disease virus from BHK 21 C 13 cells grown on the surface of DEAE sephadex A50 beads

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The production of foot‐and‐mouth disease virus from BHK 21 C 13 cells grown on the surface of DEAE sephadex A50 beads

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider