Population
BHK 21 C 13 cells (BHK monolayer cells)
Comparison
Growth on the surface of glass spheres vs GREEN BHK monolayer cells grown in Roux bottles
Design
Preclinical
Authors
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Glass sphere culture matches Roux bottles for BHK cell yield and FMD susceptibility; leaves open scalability for vaccine production.
Growing BHK monolayer cells on glass spheres is a viable method for producing foot-and-mouth disease virus, with cell yields and susceptibility comparable to traditional Roux bottle methods.
Spier et al. (1976) studied this question.
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