October 1, 1999HypertensionOpen Access

Cyclooxygenase-2 Modulates Afferent Arteriolar Responses to Increases in Pressure

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Population

Rat kidneys assessed in vitro with the blood-perfused juxtamedullary nephron technique

Comparison

Superfusion with COX-2 inhibitor NS398, with or… vs Control kidneys (basal state without inhibitors)

Design

Preclinical

Authors

AIAtsuhiro IchiharaGeneral / Preventive / Lipids JIJohn D. ImigVascular Medicine LNL. Gabriel NavarVascular Medicine

Discussion

Member takes

Implication

COX-2 metabolites may modulate rat renal autoregulation; leaves open human hypertension relevance and requires clinical translation studies.

Structured PICO

Population

Rat kidneys assessed in vitro with the blood-perfused juxtamedullary nephron technique

Intervention

Superfusion with COX-2 inhibitor NS398 (10 micromol/L), with or without nNOS inhibitor S-methyl-L-thiocitrulline (10 micromol/L), papillectomy, or furosemide (50 micromol/L)

Comparator

Control kidneys (basal state without inhibitors)

Outcome

Afferent arteriolar diameter responses to increases in perfusion pressure (from 100 mm Hg to 160 mm Hg)surrogate

COX-2-derived metabolites contribute to the nNOS modulation of pressure-mediated afferent arteriolar autoregulatory responses in rat kidneys.

Cite This Study

Ichihara et al. (1999) studied this question.

synapsesocial.com/papers/6a7652f612f355c8c708786e https://doi.org/10.1161/01.hyp.34.4.843

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Implication

COX-2 metabolites may modulate rat renal autoregulation; leaves open human hypertension relevance and requires clinical translation studies.

Cyclooxygenase-2 Modulates Afferent Arteriolar Responses to Increases in Pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cyclooxygenase-2 Modulates Afferent Arteriolar Responses to Increases in Pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider