The study provides evidence for a negative regulatory module in the interaction between RyR1 and DHPR that controls sarcoplasmic reticulum Ca2+ release, highlighting the sensitivity of RyR to long-range allosterism.
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Animal data on RyR1-DHPR allostery should not yet change clinical practice; leaves open a negative regulatory module for future studies.
Lee et al. (2004) studied this question.
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