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May 1, 1980Clinical Science

The Effects of Isoprenaline, Atropine and Dobutamine on Ventricular Volume Curves Obtained by Radionuclide Ventriculography

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Why the study?

Do isoprenaline, atropine, and dobutamine alter ventricular volume curves and mean ejection time measured by radionuclide ventriculography?

Population

22 patients undergoing radionuclide gated blood pool imaging

Comparison

Infusion of isoprenaline, atropine, or dobutamine vs Baseline (control) measurements prior to infusion

Design

Cohort

Authors

AMAlexander MuirUniversity of ChicagoWHW. J. HannanJohn Brown UniversityRSR.P. SapruYahoo (Spain)

Discussion

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Overview

Radionuclide ventriculography may detect inotropic effects on ejection fraction and time; leaves open its clinical utility beyond research settings.

Structured PICO

Do isoprenaline, atropine, and dobutamine alter ventricular volume curves and mean ejection time measured by radionuclide ventriculography?

P
Population
22 patients undergoing radionuclide gated blood pool imaging (8 received isoprenaline, 8 received atropine, 6 received dobutamine)
I
Intervention
Infusion of isoprenaline (2 μg/min), atropine (1.2 mg), or dobutamine (360 μg/min)
C
Comparator
Baseline (control) measurements prior to infusion
O
Outcome
Changes in ejection fraction, mean ejection time, and heart ratesurrogate

Radionuclide gated blood pool imaging can effectively detect early systolic changes in ventricular performance induced by inotropic agents using the mean ejection time index.

Cite This Study

Muir et al. (1980) studied this question.

synapsesocial.com/papers/6a76d06fd8eb58afc2bd6cd4https://doi.org/10.1042/cs0580357
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Assessment of Left Ventricular Ejection Fraction in Patients with Ischaemic Heart Disease by Contrast Ventriculography and Nuclear Angiography1977 · 14 citations
  2. 2Volume ejected in early systole. A sensitive index of left ventricular performance in coronary artery disease.1975 · 65 citations
  3. 3THE INFLUENCE OF HEART RATE ON LEFT VENTRICULAR VOLUME IN DOGS*1963 · 78 citations
  4. 4Comparison of Isovolumic and Ejection Phase Indices of Myocardial Performance in Man1974 · 194 citations
  5. 5Estimation of the Residual Volume of the Ventricle of the Dog's Heart by Two Indicator Dilution Technics1956 · 147 citations