Why the study?
Does increasing mean arterial pressure affect left ventricular stroke volume in newborn lambs?
Population
7 newborn lambs instrumented with vascular catheters, an electromagnetic flow transducer on the aorta, and a…
Comparison
Gradual occlusion of the aorta to increase mean… vs Baseline conditions before balloon inflation and…
Design
Preclinical
Authors
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Supports Starling mechanism in neonatal LV at constant afterload; leaves open translation to human neonates and clinical volume management.
Does increasing mean arterial pressure affect left ventricular stroke volume in newborn lambs?
This preclinical study demonstrates that the Starling mechanism is operative in newborn left ventricles when mean arterial pressure is held constant, and that the plateau in function curves during volume infusion is due to concurrent increases in afterload.
Hare et al. (1990) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: