Why the study?
Does nitric oxide synthase blockade with L-NMMA alter the cardiovascular and metabolic response to endothelin-1 infusion in healthy men?
Population
Healthy men
Comparison
Intravenous NG-monomethyl-L-arginine followed by… vs Endothelin-1 (ET-1) infusion only
Design
Other
Authors
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L-NMMA alters hemodynamics and ET-1 responses in healthy men; leaves open relevance to cardiovascular disease states or therapy.
Does nitric oxide synthase blockade with L-NMMA alter the cardiovascular and metabolic response to endothelin-1 infusion in healthy men?
Nitric oxide synthase blockade with L-NMMA induces prolonged cardiovascular effects, causes pulmonary ET-1 release, and blocks responses to ET-1 infusion, indicating that nitric oxide inhibits ET-1 production in humans.
Ahlborg et al. (1997) studied this question.
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