Key result
Additional ganglion plexus ablation improved freedom from AF or AT recurrence in patients undergoing catheter ablation, but not in those undergoing surgical ablation.
Why the study?
The effect of additional ganglion plexus ablation to pulmonary vein isolation for atrial fibrillation remained controversial between catheter and surgical-based studies.
Does additional ganglion plexus ablation improve freedom from AF or AT recurrence in patients undergoing catheter or surgical ablation for atrial fibrillation?
Meta-Analysis (n=1,750)
Does additional ganglion plexus ablation improve freedom from AF or AT recurrence in patients undergoing catheter or surgical ablation for atrial fibrillation?
Additional ganglion plexus ablation improves rhythm outcomes when combined with catheter-based PVI, but not with surgical PVI, for both paroxysmal and non-paroxysmal atrial fibrillation.
Adjunct GP ablation may improve catheter-based PVI outcomes; leaves open its role in surgical ablation and need for dedicated RCTs.
The effect of ganglion plexus (GP) ablation in addition to pulmonary veins isolation (PVI) for atrial fibrillation (AF) remained controversial between the catheter and surgical-based studies. Eleven studies (five randomized controlled trials and six nonrandomized studies) of 1750 patients were included in a meta-analysis to elucidate the incremental benefit of additional GP ablation in patients undergoing catheter or surgical ablation. Risk ratios were calculated for freedom from AF or AT recurrence after a single procedure. Additional GP ablation was associated with a better rhythm outcome for patients undergone catheter ablation but did not seem to increase freedom from AF/AT for surgical patients. Both paroxysmal and non-paroxysmal AF showed a positive outcome comparing additional GP ablation with PVI alone.
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Yan et al. (2019) conducted a meta-analysis in Atrial fibrillation (n=1,750). Ganglion plexus (GP) ablation in addition to pulmonary veins isolation (PVI) vs. PVI alone was evaluated on Freedom from AF or AT recurrence after a single procedure. Additional ganglion plexus ablation improved freedom from AF or AT recurrence in patients undergoing catheter ablation, but not in those undergoing surgical ablation.
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