December 1, 2000AJP Cell Physiology

Protein kinase C contributes to desensitization of ANG II signaling in adult rat cardiac fibroblasts

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Population

Primary cultures of adult rat cardiac fibroblasts

Comparison

Pharmacological modulation of PKC in the… vs ANG II alone

Design

Preclinical

Authors

JMJ. Gary MeszarosAlliant Techsystems (United States)RRRobert RaphaelPalmetto Hematology Oncology FLFrancisco M. LioNeurocrine Biosciences (United States)

Discussion

Member takes

Implication

Should not yet inform clinical ANG II therapies; leaves open PKC feedback relevance in human cardiac fibroblasts.

Structured PICO

Population

Primary cultures of adult rat cardiac fibroblasts

Intervention

Pharmacological modulation of PKC (inhibition with staurosporine or GF-109203X, depletion with overnight PMA, or acute activation with PMA) in the presence of ANG II

Comparator

ANG II alone

Outcome

Inositol phosphate (IP) accumulation and Ca(2+) mobilizationsurrogate

In adult rat cardiac fibroblasts, ANG II signaling is rapidly desensitized via a PKC-mediated negative feedback loop.

Cite This Study

Meszaros et al. (2000) studied this question.

synapsesocial.com/papers/6a779b00137c7dcc81bdefc0 https://doi.org/10.1152/ajpcell.2000.279.6.c1978

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Protein kinase C contributes to desensitization of ANG II signaling in adult rat cardiac fibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protein kinase C contributes to desensitization of ANG II signaling in adult rat cardiac fibroblasts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider