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June 1, 1997AJP Heart and Circulatory Physiology

Effect of ventricular contraction, pressure, and wall stretch on vessels at different locations in the wall

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Population

Cylindrical model of the heart and a small piece of rectangular myocardium containing a vessel

Design

Preclinical

Authors

MVM. A. VisVrije Universiteit AmsterdamPBPeter H. M. BovendeerdEindhoven University of TechnologyPSP. SipkemaRijnstate Hospital

Discussion

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Implication

Greater arteriolar resistance increases during contraction should not change practice; leaves open contractility dominance in human coronary regulation.

Structured PICO

P
Population
Cylindrical model of the heart and a small piece of rectangular myocardium containing a vessel
I
Intervention
Ventricular filling and (isovolumic and isobaric) contraction
O
Outcome
Cross-sectional area and resistance of a subendocardial and subepicardial maximally dilated arteriole and venulesurrogate

This computational model demonstrates that contractility is the main contributor to changes in vascular area and resistance in the subepicardium, while pressure and stretch contributions vary depending on the type of contraction.

Cite This Study

Vis et al. (1997) studied this question.

synapsesocial.com/papers/6a77c204d8eb58afc2be1b0ahttps://doi.org/10.1152/ajpheart.1997.272.6.h2963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modeling pressure-area relations of coronary blood vessels embedded in cardiac muscle in diastole and systole1995 · 23 citations
  2. 2Coronary artery resistance changes depend on how surrounding myocardial tissue is stretched1996 · 9 citations
  3. 3Vasomotor tone affects diastolic coronary flow and flow impediment by cardiac contraction similarly1994 · 8 citations
  4. 4Morphometry of canine coronary arteries, arterioles, and capillaries during hypertension and left ventricular hypertrophy.1986 · 184 citations
  5. 5Effect of perfusion pressure on force of contraction in thin papillary muscles and trabeculae from rat heart.1992 · 49 citations