February 1, 1996Annual Review of Medicine

Myocardial Preconditioning Promises to Be a Novel Approach to the Treatment of Ischemic Heart Disease

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Why the study?

Does ischemic preconditioning improve myocardial function and diminish infarction in ischemic heart disease?

Population

Experimental animals and humans

Design

Review

Authors

MCMichael V. CohenEast Tennessee State University JDJames M. DowneyUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Does not support clinical adoption of ischemic preconditioning; leaves open PKC pathway translation to therapies in ischemic heart disease.

Structured PICO

Does ischemic preconditioning improve myocardial function and diminish infarction in ischemic heart disease?

Population

Experimental animals and humans

Intervention

Ischemic preconditioning (brief period of ischemia prior to a more prolonged one) or pharmacological agonists coupled to protein kinase C (adenosine, angiotensin, phenylephrine, bradykinin, endothelin)

Outcome

Myocardial function after reperfusion and infarction size

Understanding the mechanisms of ischemic preconditioning, particularly the role of PKC, may lead to novel routine treatments to salvage ischemic myocardium in patients with ischemic heart disease.

Limitations

Specific protein phosphorylated by PKC is not yet known
Identity of the end-effector that actually mediates protection of the ischemic cell is not yet known

Cite This Study

Cohen et al. (1996) studied this question.

synapsesocial.com/papers/6a77c27d137c7dcc81be0bdc https://doi.org/10.1146/annurev.med.47.1.21

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Implication

Does not support clinical adoption of ischemic preconditioning; leaves open PKC pathway translation to therapies in ischemic heart disease.

Myocardial Preconditioning Promises to Be a Novel Approach to the Treatment of Ischemic Heart Disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Myocardial Preconditioning Promises to Be a Novel Approach to the Treatment of Ischemic Heart Disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider