Genetic complementation among poliovirus mutants derived from an infectious cDNA clone
Population
Poliovirus type I (Mahoney strain) mutants derived from an infectious cDNA clone
Comparison
Mixed infections with different pairs of mutants vs Single infections
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Suggests distinct poliovirus complementation groups; leaves open cis-acting functions as antiviral targets.
Structured PICO
P
Population
Poliovirus type I (Mahoney strain) mutants derived from an infectious cDNA clone
I
Intervention
Mixed infections with different pairs of mutants
C
Comparator
Single infections
O
Outcome
Yields of progeny virus (genetic complementation)surrogate
The nonstructural portion of the poliovirus genome contains multiple complementation groups, with evidence suggesting certain nonstructural functions act only in cis.
Cite This Study
Bernstein et al. (1986) studied this question.