Why the study?
Does treatment of acute severe heart failure influence plasma levels of natriuretic peptides, renin, neuropeptide Y, and catecholamines in patients with NYHA class IV heart failure?
Population
9 hospital in-patients with acute New York Heart Association (NYHA) class IV heart failure
Comparison
Treatment of acute heart failure vs Baseline (before treatment)
Design
Case_series
Authors
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Natriuretic peptides may track acute severe HF response; single case leaves renin dynamics and generalizability open.
Does treatment of acute severe heart failure influence plasma levels of natriuretic peptides, renin, neuropeptide Y, and catecholamines in patients with NYHA class IV heart failure?
In acute severe heart failure, plasma BNP and ANP are markedly elevated and fall with treatment, whereas the circulating renin-angiotensin-aldosterone system is not significantly activated prior to treatment.
Missouris et al. (1998) studied this question.
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