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June 1, 1992Journal of Cellular Physiology

Endothelium‐derived relaxing factor contributes to the regulation of endothelial permeability

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Population

Monolayers of bovine aortic endothelial cells grown on collagen-coated filters

Comparison

Modulation of EDRF/nitric oxide pathway using… vs Control conditions

Design

Preclinical

Authors

JOJuan OliverSuzuki (Japan)

Discussion

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Implication

L-arginine modulation of endothelial permeability in animal models should not change practice; leaves open nitric oxide effects on vascular barrier function in vivo.

Structured PICO

P
Population
Monolayers of bovine aortic endothelial cells grown on collagen-coated filters
I
Intervention
Modulation of EDRF/nitric oxide pathway using L-arginine depletion/administration, bradykinin, and various inhibitors/activators (e.g., 8-Bromoguanosine 3',5'-cyclic monophosphate, glyceryl trinitrate, methylene blue, oxyhemoglobin, NG-methyl-L-arginine, N omega-nitro-L-arginine)
C
Comparator
Control conditions (baseline or untreated monolayers)
O
Outcome
Transendothelial flux of 14C-sucrose (permeability coefficient)surrogate

Endothelium-derived relaxing factor (EDRF) contributes to the sealing of the endothelial monolayer and acts as a feedback inhibitor to attenuate increases in endothelial permeability induced by agents like bradykinin.

Cite This Study

Juan Oliver (1992) studied this question.

synapsesocial.com/papers/6a78c12c2e130d02afed4bb6https://doi.org/10.1002/jcp.1041510309
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelium‐derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells1988 · 128 citations
  2. 2Short- and long-term interactions of endothelium and vascular smooth muscle in coculture: effects on cyclic GMP production.1986 · 56 citations
  3. 3Role of protein kinase C in bradykinin-induced increases in microvascular permeability.1991 · 98 citations